The curriculum at St. Katharine Drexel School is aligned with the South Dakota Content State Standards (SDCSS). The SDCSS focus on increasing academic rigor and meeting grade-level expectations, as well as fostering conceptual understanding and real life problem solving skills. St. Katharine Drexel School seeks to educate the whole child through its strong academic programs while meeting individual student needs. The school has rigorous expectations in instruction with a curriculum that addresses faith development in addition to the traditional academic curriculum. Students receive instruction in the areas of language arts, mathematics, science, and social studies. In addition to these main content areas, students receive instruction in religion, physical education, visual arts, vocal, instrumental music, technology, library, and guidance counseling. Teachers consistently reflect on and analyze data in order to employ a variety of instructional strategies that motivate and engage all learners.